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Prozac Weekly is a capsule with pellets containing 90 mg of fluoxetine hydrochloride.The enteric coating prevents dissolution of the pellets until they have passed into the portion of the gastrointestinal tract where the p H exceeds 5.5.6 In a study8 of 500 patients with depression, the percentage of patients relapsing during continuation treatment with a 90-mg weekly dose was not significantly different from those taking a 20-mg daily dose. Weekly dosing is recommended to begin seven days after the last daily dose of 20 mg .The most common side effects of sertraline are nausea, dry mouth, fatigue, and decreased libido.Treatment with sertraline should be started at 50 mg, either daily throughout the month or daily during the luteal phase of the menstrual cycle.

Improvement in symptoms of tension, irritability, and dysphoria has been demonstrated.9 [Evidence level A, randomized controlled trial (RCT)] Side effects were comparable with those reported in studies of fluoxetine used for other indications.According to a recent survey1 of the most common reasons for patient visits to family physicians in the United States, depression and anxiety ranked 11th and 17th, respectively.Ten to 20 percent of adults in the United States experience depression at some point in their lifetime.2 Many antidepressants have been released in the United States over the past two decades.The newest indication for sertraline is the treatment of PMDD.Sertraline has been shown to improve quality-of-life scores and psychologic and behavior symptoms in patients with PMDD.1516 [Reference 15—Evidence level A, RCT] Its effectiveness has been demonstrated with both continuous dosing throughout the month and luteal-phase dosing.

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